Selected article for: "acute lung injury and cell type"
Author: Allen Wang; Joshua A Chiou; Olivier B Poirion; Justin Buchanan; Michael J Valdez; Jamie M Verheyden; Xiaomeng Hou; Minzhe Guo; Jacklyn M Newsome; Parul Kudtarkar; Dina A Faddah; Kai Zhang; Randee E Young; Justinn Barr; Ravi Misra; Heidie Huyck; Lisa Rogers; Cory Poole; Jeffery A Whitsett; Gloria Pryhuber; Yan Xu; Kyle J Gaulton; Sebastian Preissl; Xin Sun
Title: Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection
  • Document date: 2020_4_14
    • ID: 5kvq6jtx_42
    Snippet: we caution that inhibiting ACE2 expression should not be a recommended strategy. Aside 512 from being a viral receptor gene, ACE2 is also required for protecting the lung from injury-513 induced acute respiratory distress phenotypes, the precise cause of COVID-19 mortality 514 In this study, we present the first snATAC-seq dataset of the human lung and 523 complementary snRNA-seq data from the same samples. Here, we used COVID-19 524 genes to dem.....
    Document: we caution that inhibiting ACE2 expression should not be a recommended strategy. Aside 512 from being a viral receptor gene, ACE2 is also required for protecting the lung from injury-513 induced acute respiratory distress phenotypes, the precise cause of COVID-19 mortality 514 In this study, we present the first snATAC-seq dataset of the human lung and 523 complementary snRNA-seq data from the same samples. Here, we used COVID-19 524 genes to demonstrate how this dataset can be utilized. As COVID-19 GWAS data 525 emerge, our datasets will offer a powerful cell type-resolved platform to interrogate 526 mechanisms that may underlie genetic differences in the susceptibility and response to 527 SARS-CoV-2 infection. Furthermore, our results suggest that modulation of the interferon 528 pathway is a possible avenue to restrict TMPRSS2 expression and viral entry. 529

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