Author: Allen Wang; Joshua A Chiou; Olivier B Poirion; Justin Buchanan; Michael J Valdez; Jamie M Verheyden; Xiaomeng Hou; Minzhe Guo; Jacklyn M Newsome; Parul Kudtarkar; Dina A Faddah; Kai Zhang; Randee E Young; Justinn Barr; Ravi Misra; Heidie Huyck; Lisa Rogers; Cory Poole; Jeffery A Whitsett; Gloria Pryhuber; Yan Xu; Kyle J Gaulton; Sebastian Preissl; Xin Sun
Title: Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection Document date: 2020_4_14
ID: 5kvq6jtx_42
Snippet: we caution that inhibiting ACE2 expression should not be a recommended strategy. Aside 512 from being a viral receptor gene, ACE2 is also required for protecting the lung from injury-513 induced acute respiratory distress phenotypes, the precise cause of COVID-19 mortality 514 In this study, we present the first snATAC-seq dataset of the human lung and 523 complementary snRNA-seq data from the same samples. Here, we used COVID-19 524 genes to dem.....
Document: we caution that inhibiting ACE2 expression should not be a recommended strategy. Aside 512 from being a viral receptor gene, ACE2 is also required for protecting the lung from injury-513 induced acute respiratory distress phenotypes, the precise cause of COVID-19 mortality 514 In this study, we present the first snATAC-seq dataset of the human lung and 523 complementary snRNA-seq data from the same samples. Here, we used COVID-19 524 genes to demonstrate how this dataset can be utilized. As COVID-19 GWAS data 525 emerge, our datasets will offer a powerful cell type-resolved platform to interrogate 526 mechanisms that may underlie genetic differences in the susceptibility and response to 527 SARS-CoV-2 infection. Furthermore, our results suggest that modulation of the interferon 528 pathway is a possible avenue to restrict TMPRSS2 expression and viral entry. 529
Search related documents:
Co phrase search for related documents- acute respiratory distress phenotype and human lung: 1
- acute respiratory distress phenotype and respiratory distress phenotype: 1, 2, 3, 4, 5, 6, 7
- acute respiratory distress phenotype and sars infection: 1, 2
- acute respiratory distress phenotype and viral entry: 1, 2
- cell type and human lung: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65
- cell type and human lung snATAC seq dataset: 1
- cell type and precise cause: 1
- cell type and receptor gene: 1, 2, 3, 4, 5, 6
- cell type and sars infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- cell type and snATAC seq: 1, 2, 3, 4, 5
- cell type and snATAC seq dataset: 1
- cell type and snrna seq: 1, 2, 3, 4, 5, 6
- cell type and viral entry: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- distress phenotype and human lung: 1
- distress phenotype and respiratory distress phenotype: 1, 2, 3, 4, 5, 6, 7
- distress phenotype and sars infection: 1, 2
- distress phenotype and viral entry: 1, 2
- genetic difference and receptor gene: 1, 2
- genetic difference and sars infection: 1, 2
Co phrase search for related documents, hyperlinks ordered by date