Author: Wei Lin; Longfei Hu; Yan Zhang; Joshua D. Ooi; Ting Meng; Peng Jin; Xiang Ding; Longkai Peng; Lei Song; Zhou Xiao; Xiang Ao; Xiangcheng Xiao; Qiaoling Zhou; Ping Xiao; Jue Fan; Yong Zhong
Title: Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection Document date: 2020_2_18
ID: mm2sp48e_13
Snippet: By analyzing the public single-cell transcriptome dataset of normal human kidney cells from three donors 14 , we found ACE2 expression distributed across multiple cell types. Notably, ACE2 was mostly enriched in proximal tubule cells, including both convoluted tubule and straight tubule (Fig 1A-D) . The other nephron subtypes, such as collecting duct and distal tubule as well as immune cells, all showed extremely low gene expressions......
Document: By analyzing the public single-cell transcriptome dataset of normal human kidney cells from three donors 14 , we found ACE2 expression distributed across multiple cell types. Notably, ACE2 was mostly enriched in proximal tubule cells, including both convoluted tubule and straight tubule (Fig 1A-D) . The other nephron subtypes, such as collecting duct and distal tubule as well as immune cells, all showed extremely low gene expressions.
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