Author: Eric Anthony Coomes; Hourmazd Haghbayan
Title: Interleukin-6 in COVID-19: A Systematic Review and Meta-Analysis Document date: 2020_4_3
ID: nadcsiii_29
Snippet: . CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (Table 3) . Of these, all are based in China; one has since been cancelled by the principal investigator and one is planned but not yet recruiting. Two of the studies underway are multi-centre RCTs, with a third RCT pending recruitment. The cumulative anticipated sample size for the four plan.....
Document: . CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (Table 3) . Of these, all are based in China; one has since been cancelled by the principal investigator and one is planned but not yet recruiting. Two of the studies underway are multi-centre RCTs, with a third RCT pending recruitment. The cumulative anticipated sample size for the four planned studies will be n=518 and the methodological designs are complementary in target patient populations (all-comers, allcomers with elevated IL-6, severe cases with elevated IL-6, and severe cases with elevated IL-6 meeting diagnostic criteria for grade 2-3 CRS) and comparators (supportive therapy, favipiravir, continuous renal replacement therapy).
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