Selected article for: "meta analysis and statistical analysis"
Author: Eric Anthony Coomes; Hourmazd Haghbayan
Title: Interleukin-6 in COVID-19: A Systematic Review and Meta-Analysis
  • Document date: 2020_4_3
    • ID: nadcsiii_42
    Snippet: We encountered high levels of statistical heterogeneity in our meta-analysis comparing IL-6 levels between patients with complicated and non-complicated disease; although we performed pre-specified sensitivity analyses, these failed to sufficiently explain this heterogeneity. Such residual heterogeneity may have arisen from multiple sources of variability between studies, most prominently due to likely differences in patient characteristics, lack.....
    Document: We encountered high levels of statistical heterogeneity in our meta-analysis comparing IL-6 levels between patients with complicated and non-complicated disease; although we performed pre-specified sensitivity analyses, these failed to sufficiently explain this heterogeneity. Such residual heterogeneity may have arisen from multiple sources of variability between studies, most prominently due to likely differences in patient characteristics, lack of consecutive enrolment, variable timing of IL-6 measurement, the absence of a set definition of "supportive care", and differences in adjuvant immunomodulatory medications received, such as corticosteroids and IVIg, which may have affected both IL-6 response and patient outcomes.

    Search related documents:
    Co phrase search for related documents
    • complicated non complicated disease and non complicated disease: 1
    • heterogeneity explain and high level: 1
    • heterogeneity explain and meta analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • high level and meta analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • high level and multiple source: 1
    • high level and patient outcome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • likely difference and meta analysis: 1, 2, 3
    • meta analysis and multiple source: 1
    • meta analysis and non complicated disease: 1, 2
    • meta analysis and patient characteristic: 1
    • meta analysis and patient outcome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • multiple source and patient outcome: 1