Selected article for: "dmbt1 expression and viral pathogen"
Author: Guangchun Han; Ansam Sinjab; Warapen Treekitkarnmongkol; Patrick Brennan; Kieko Hara; Kyle Chang; Elena Bogatenkova; Beatriz Sanchez-Espiridion; Carmen Behrens; Boning Gao; Luc Girard; Jianjun Zhang; Boris Sepesi; Tina Cascone; Lauren Byers; Don L. Gibbons; Jichao Chen; Seyed Javad Moghaddam; Edwin J. Ostrin; Junya Fujimoto; Jerry Shay; John V. Heymach; John D. Minna; Steven Dubinett; Paul A. Scheet; Ignacio I. Wistuba; Edward Hill; Shannon Telesco; Christopher Stevenson; Avrum E. Spira; Linghua Wang; Humam Kadara
Title: Single-cell analysis of human lung epithelia reveals concomitant expression of the SARS-CoV-2 receptor ACE2 with multiple virus receptors and scavengers in alveolar type II cells
  • Document date: 2020_4_17
    • ID: j3vruni3_32
    Snippet: A notable finding in our study was the co-expression of pathogen including viral scavengers and receptors such as CD36 and DMBT1 in ACE2-positive AT2 cells. We also found that among all lung subsets, AT2 cells distinctly and markedly displayed the highest expression of DMBT1. Further, DMBT1 correlated with AT2 fractions in independent cohorts of bulk-sequenced lung tissues and positive correlated with ACE2 in the AT2 compartment. DMBT1, also know.....
    Document: A notable finding in our study was the co-expression of pathogen including viral scavengers and receptors such as CD36 and DMBT1 in ACE2-positive AT2 cells. We also found that among all lung subsets, AT2 cells distinctly and markedly displayed the highest expression of DMBT1. Further, DMBT1 correlated with AT2 fractions in independent cohorts of bulk-sequenced lung tissues and positive correlated with ACE2 in the AT2 compartment. DMBT1, also known as gp340, was shown to inhibit influenza A by binding to hemagglutinin (HA) on the virus 55 . DMBT1 was also shown to interact with surfactant protein D (SFTPD) in alveolar cells to agglutinate and inhibit influenza A virus 38 . It has been suggested that the antiviral drug oseltamivir cooperates with innate immune proteins such as

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