Author: Jieyu Guo; Xiangxiang Wei; Qinhan Li; Liliang Li; Zhaohua Yang; Yu Shi; Yue Qin; Xinyue Zhang; Xinhong Wang; Xiuling Zhi; Dan Meng
Title: Single-cell RNA Analysis on ACE2 Expression Provides Insight into SARS-CoV-2 Blood Entry and Heart Injury Document date: 2020_4_4
ID: in3b1nzv_23
Snippet: The first destination of pulmonary circulation outflow is the heart. Therefore, we assume that SARS-CoV-2 may attack the heart through the blood flow, which may explain the high incidence of cardiac injury in critical patients 12 . Also, heart failure samples displayed a more substantial proportion of ACE2 positive cells in cardiomyocytes and higher overall expression of ACE2 than the normal heart, which might explain why patients with underlying.....
Document: The first destination of pulmonary circulation outflow is the heart. Therefore, we assume that SARS-CoV-2 may attack the heart through the blood flow, which may explain the high incidence of cardiac injury in critical patients 12 . Also, heart failure samples displayed a more substantial proportion of ACE2 positive cells in cardiomyocytes and higher overall expression of ACE2 than the normal heart, which might explain why patients with underlying heart diseases were correlated with higher mortality. Thus, preventing SARS-CoV-2 from entering the bloodstream may reduce the chance of myocardial damage in patients with underlying heart diseases. In contrast, the lower proportion of ACE2-expressing cells in arterial vascular cells of failed hearts All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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