Adaptive multi-channel event segmentation and feature extraction for monitoring health outcomes.

She, Xichen; Zhai, Yaya; Henao, Ricardo; Woods, Christopher; Chiu, Christopher; Ginsburg, Geoffrey S; Song, Peter X K; Hero, Alfred O

OBJECTIVE To develop a multi-channel device event segmentation and feature extraction algorithm that is robust to changes in data distribution. METHODS We introduce an adaptive transfer learning algorithm to classify and segment events from non-stationary multi-channel temporal data. Using a multivariate hidden Markov model (HMM) and Fisher's linear discriminant analysis (FLDA) the algorithm adaptively adjusts to shifts in distribution over time. The proposed algorithm is unsupervised and learns to label events without requiring \textit{a priori} information about true event states. The procedure is illustrated on experimental data collected from a cohort in a human viral challenge (HVC) study, where certain subjects have disrupted wake and sleep patterns after exposure to a H1N1 influenza pathogen. RESULTS Simulations establish that the proposed adaptive algorithm significantly outperforms other event classification methods. When applied to early time points in the HVC data the algorithm extracts sleep/wake features that are predictive of both infection and infection onset time. CONCLUSION The proposed transfer learning event segmentation method is robust to temporal shifts in data distribution and can be used to produce highly discriminative event-labeled features for health monitoring. SIGNIFICANCE Our integrated multisensor signal processing and transfer learning method is applicable to many ambulatory monitoring applications.