Author: Allen Wang; Joshua A Chiou; Olivier B Poirion; Justin Buchanan; Michael J Valdez; Jamie M Verheyden; Xiaomeng Hou; Minzhe Guo; Jacklyn M Newsome; Parul Kudtarkar; Dina A Faddah; Kai Zhang; Randee E Young; Justinn Barr; Ravi Misra; Heidie Huyck; Lisa Rogers; Cory Poole; Jeffery A Whitsett; Gloria Pryhuber; Yan Xu; Kyle J Gaulton; Sebastian Preissl; Xin Sun
Title: Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection Document date: 2020_4_14
ID: 5kvq6jtx_1
Snippet: snRNA-seq and snATAC-seq data. This combination allowed us to associate cell type-140 specific accessible chromatin profiles that may act as cis-regulatory regions that control 141 cell-type specific gene expression. Using these data, we first addressed cell-type 142 specificity and temporal dynamics of ACE2, TMPRSS2, CTSL, BSG, and FURIN 143 expression. We next identified candidate cis-regulatory elements co-accessible with the 144 promoters of .....
Document: snRNA-seq and snATAC-seq data. This combination allowed us to associate cell type-140 specific accessible chromatin profiles that may act as cis-regulatory regions that control 141 cell-type specific gene expression. Using these data, we first addressed cell-type 142 specificity and temporal dynamics of ACE2, TMPRSS2, CTSL, BSG, and FURIN 143 expression. We next identified candidate cis-regulatory elements co-accessible with the 144 promoters of these genes and characterized their cell-type specificity and temporal 145 dynamics. Finally, we profiled sequence variation that may impact cis-regulatory element 146 activity and contribute to differential susceptibility to SARS-CoV-2 infection. 147
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