Author: Allen Wang; Joshua A Chiou; Olivier B Poirion; Justin Buchanan; Michael J Valdez; Jamie M Verheyden; Xiaomeng Hou; Minzhe Guo; Jacklyn M Newsome; Parul Kudtarkar; Dina A Faddah; Kai Zhang; Randee E Young; Justinn Barr; Ravi Misra; Heidie Huyck; Lisa Rogers; Cory Poole; Jeffery A Whitsett; Gloria Pryhuber; Yan Xu; Kyle J Gaulton; Sebastian Preissl; Xin Sun
Title: Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection Document date: 2020_4_14
ID: 5kvq6jtx_17
Snippet: To identify specific cis-regulatory elements that might control cell type-restricted 316 expression of the SARS-CoV-2 viral entry genes in the lung, we aggregated cells within 317 each cell type and called accessible chromatin sites from the aggregated profiles using 318 MACS2 (Zhang et al., 2008) . We then identified sites mapping within 650kb of each 319 SARS-CoV-2 viral entry gene, and further identified sites that were co-accessible with the .....
Document: To identify specific cis-regulatory elements that might control cell type-restricted 316 expression of the SARS-CoV-2 viral entry genes in the lung, we aggregated cells within 317 each cell type and called accessible chromatin sites from the aggregated profiles using 318 MACS2 (Zhang et al., 2008) . We then identified sites mapping within 650kb of each 319 SARS-CoV-2 viral entry gene, and further identified sites that were co-accessible with the 320 gene promoter using Cicero (Pliner et al., 2018) . At the ACE2 locus, we identified 165 321 accessible chromatin sites mapping within the ±650kb window ( Figure 2C , 322
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