Author: Allen Wang; Joshua A Chiou; Olivier B Poirion; Justin Buchanan; Michael J Valdez; Jamie M Verheyden; Xiaomeng Hou; Minzhe Guo; Jacklyn M Newsome; Parul Kudtarkar; Dina A Faddah; Kai Zhang; Randee E Young; Justinn Barr; Ravi Misra; Heidie Huyck; Lisa Rogers; Cory Poole; Jeffery A Whitsett; Gloria Pryhuber; Yan Xu; Kyle J Gaulton; Sebastian Preissl; Xin Sun
Title: Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection Document date: 2020_4_14
ID: 5kvq6jtx_40
Snippet: In our lung snRNA-seq data, ACE2 is detected in a very small number of cells, a 501 the possibility that ACE2 may not be needed at high levels for viral attachment to host 506 cells. Alternatively, it is plausible that alternative receptors such as BSG also facilitate 507 SARS-CoV-2 attachment in vivo. Compared to ACE2, BSG is expressed and co-508 . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright ho.....
Document: In our lung snRNA-seq data, ACE2 is detected in a very small number of cells, a 501 the possibility that ACE2 may not be needed at high levels for viral attachment to host 506 cells. Alternatively, it is plausible that alternative receptors such as BSG also facilitate 507 SARS-CoV-2 attachment in vivo. Compared to ACE2, BSG is expressed and co-508 . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.12.037580 doi: bioRxiv preprint expressed with proteases in a higher fraction of nuclei in AT2 and in additional cell types 509 in the human lung. 510
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