Selected article for: "direct interaction and infection source"
Author: Anne Louise Wyllie; John Fournier; Arnau Casanovas-Massana; Melissa Campbell; Maria Tokuyama; Pavithra Vijayakumar; Bertie Geng; M. Catherine Muenker; Adam J. Moore; Chantal B. F. Vogels; Mary E. Petrone; Isabel M. Ott; Peiwen Lu; Alice Lu-Culligan; Jonathan Klein; Arvind Venkataraman; Rebecca Earnest; Michael Simonov; Rupak Datta; Ryan Handoko; Nida Naushad; Lorenzo R. Sewanan; Jordan Valdez; Elizabeth B. White; Sarah Lapidus; Chaney C. Kalinich; Xiaodong Jiang; Daniel J. Kim; Eriko Kudo; Melissa Linehan; Tianyang Mao; Miyu Moriyama; Ji Eun Oh; Annsea Park; Julio Silva; Eric Song; Takehiro Takahashi; Manabu Taura; Orr-El Weizman; Patrick Wong; Yexin Yang; Santos Bermejo; Camila Odio; Saad B. Omer; Charles S. Dela Cruz; Shelli Farhadian; Richard A. Martinello; Akiko Iwasaki; Nathan D. Grubaugh; Albert I. Ko
Title: Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs
  • Document date: 2020_4_22
    • ID: lt7qsxxh_14
    Snippet: Our study demonstrates that saliva is a viable and preferable alternative to nasopharyngeal swabs for SARS-CoV-2 detection. We found that the sensitivity of SARS-CoV-2 detection from saliva is comparable, if not superior to nasopharyngeal swabs in early hospitalization and is more consistent during extended hospitalization and recovery. Moreover, the detection of SARS-CoV-2 from the saliva of two asymptomatic healthcare workers despite negative m.....
    Document: Our study demonstrates that saliva is a viable and preferable alternative to nasopharyngeal swabs for SARS-CoV-2 detection. We found that the sensitivity of SARS-CoV-2 detection from saliva is comparable, if not superior to nasopharyngeal swabs in early hospitalization and is more consistent during extended hospitalization and recovery. Moreover, the detection of SARS-CoV-2 from the saliva of two asymptomatic healthcare workers despite negative matched nasopharyngeal swabs suggests that saliva may also be a viable alternative for identifying mild or subclinical infections. With further validation, widespread implementation of saliva sampling could be transformative for public health efforts: saliva self-collection negates the need for direct healthcare worker-patient interaction, a source of several major testing bottlenecks and overall nosocomial infection risk [14] [15] [16] , and alleviates supply demands on swabs and personal protective equipment.

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