Author: Wei Lin; Longfei Hu; Yan Zhang; Joshua D. Ooi; Ting Meng; Peng Jin; Xiang Ding; Longkai Peng; Lei Song; Zhou Xiao; Xiang Ao; Xiangcheng Xiao; Qiaoling Zhou; Ping Xiao; Jue Fan; Yong Zhong
Title: Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection Document date: 2020_2_18
ID: mm2sp48e_19
Snippet: The etiology of AKI in SARS seems to be multifactorial and still uncertain, which was thought to have a certain correlation with the high expression of ACE2 in the kidney 24 25 . Based on our single-cell analysis in both normal kidneys and bladders, we found both detectable levels of ACE2 in kidney and bladder. Kidney PT cells have higher expression percentages than bladder epithelial cells, which may indicate that kidney is more susceptible to 2.....
Document: The etiology of AKI in SARS seems to be multifactorial and still uncertain, which was thought to have a certain correlation with the high expression of ACE2 in the kidney 24 25 . Based on our single-cell analysis in both normal kidneys and bladders, we found both detectable levels of ACE2 in kidney and bladder. Kidney PT cells have higher expression percentages than bladder epithelial cells, which may indicate that kidney is more susceptible to 2019-nCoV infection than bladder. Comparing to the expression levels of ACE2 in the digestion system 11 the lower expression of ACE2 in the renal and urinary system could suggest fewer patients with renal related symptoms, which positively correlates with the observations for SARS patients.
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