Author: Alpana Waghmare; Elizabeth M Krantz; Subhasish Baral; Emma Vasquez; Tillie Loeffelholz; E. Lisa Chung; Urvashi Pandey; Jane Kuypers; Elizabeth R Duke; Keith R Jerome; Alexander L Greninger; Daniel B Reeves; Florian Hladik; E Fabian Cardozo-Ojeda; Michael Boeckh; Joshua T Schiffer
Title: Reliability of self-sampling for accurate assessment of respiratory virus viral and immunologic kinetics Document date: 2020_4_6
ID: 89s17ytr_10
Snippet: In Fig 4a, we show our resulting model schematic. Differential equations capture the rate of 215 change of susceptible cells, infected cells, viral load (Fig 4b) and two cytokines (Fig 4c-d) . The 216 best fit was achieved with a model assuming IFNγ concentration dependent killing during the 217 first early stages of infection, and IL-21 mediated elimination of infected cells with a mechanism 218 saturating the amount of possible killing above a.....
Document: In Fig 4a, we show our resulting model schematic. Differential equations capture the rate of 215 change of susceptible cells, infected cells, viral load (Fig 4b) and two cytokines (Fig 4c-d) . The 216 best fit was achieved with a model assuming IFNγ concentration dependent killing during the 217 first early stages of infection, and IL-21 mediated elimination of infected cells with a mechanism 218 saturating the amount of possible killing above a certain level of IL-21. 219 220
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