Author: Leal, Carla Monteiro; Leitão, Suzana Guimarães; Sausset, Romain; Mendonça, Simony C.; Nascimento, Pedro H. A.; de Araujo R. Cheohen, Caio Felipe; Esteves, Maria Eduarda A.; Leal da Silva, Manuela; Gondim, Tayssa Santos; Monteiro, Maria Eduarda S.; Tucci, Amanda Resende; Fintelman-Rodrigues, Natália; Siqueira, Marilda M.; Miranda, Milene Dias; Costa, Fernanda N.; Simas, Rosineide C.; Leitão, Gilda Guimarães
Title: Flavonoids from Siparuna cristata as Potential Inhibitors of SARS-CoV-2 Replication Cord-id: smagmbuy Document date: 2021_7_20
ID: smagmbuy
Snippet: The novel coronavirus SARS-CoV-2 has been affecting the world, causing severe pneumonia and acute respiratory syndrome, leading people to death. Therefore, the search for anti-SARS-CoV-2 compounds is pivotal for public health. Natural products may present sources of bioactive compounds; among them, flavonoids are known in literature for their antiviral activity. Siparuna species are used in Brazilian folk medicine for the treatment of colds and flu. This work describes the isolation of 3,3′,4â
Document: The novel coronavirus SARS-CoV-2 has been affecting the world, causing severe pneumonia and acute respiratory syndrome, leading people to death. Therefore, the search for anti-SARS-CoV-2 compounds is pivotal for public health. Natural products may present sources of bioactive compounds; among them, flavonoids are known in literature for their antiviral activity. Siparuna species are used in Brazilian folk medicine for the treatment of colds and flu. This work describes the isolation of 3,3′,4′-tri-O-methyl-quercetin, 3,7,3′,4′-tetra-O-methyl-quercetin (retusin), and 3,7-di-O-methyl-kaempferol (kumatakenin) from the dichloromethane extract of leaves of Siparuna cristata (Poepp. & Endl.) A.DC., Siparunaceae, using high-speed countercurrent chromatography in addition to the investigation of their inhibitory effect against SARS-CoV-2 viral replication. Retusin and kumatakenin inhibited SARS-CoV-2 replication in Vero E6 and Calu-3 cells, with a selective index greater than lopinavir/ritonavir and chloroquine, used as control. Flavonoids and their derivatives may stand for target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s43450-021-00162-5.
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