Author: Huayan Xu; Keke Hou; Hong Xu; Zhenlin Li; Huizhu Chen; Na Zhang; Rong Xu; Hang Fu; Ran Sun; Lingyi Wen; Linjun Xie; Hui Liu; Kun Zhang; Joseph B Selvanayagam; Chuan Fu; Shihua Zhao; Zhigang Yang; Ming Yang; Yingkun Guo
Title: Acute Myocardial Injury of Patients with Coronavirus Disease 2019 Document date: 2020_3_8
ID: jg6v644y_2
Snippet: Since its first emergence in Wuhan city in late December 2019, COVID-19 has already spread to 26 countries. As of March 02, 2020, there were over 87137 confirmed cases worldwide, with 2977 deaths. 1 To date, several latest studies have reported the clinical characteristics of hospitalized patients with 2019 novel coronavirus pneumonia (NCP), including signs, symptoms, laboratory test results, imaging features, therapeutic strategies and effects, .....
Document: Since its first emergence in Wuhan city in late December 2019, COVID-19 has already spread to 26 countries. As of March 02, 2020, there were over 87137 confirmed cases worldwide, with 2977 deaths. 1 To date, several latest studies have reported the clinical characteristics of hospitalized patients with 2019 novel coronavirus pneumonia (NCP), including signs, symptoms, laboratory test results, imaging features, therapeutic strategies and effects, and multiple organ dysfunction. [2] [3] [4] [5] Notably, acute myocardial injury (AMI), defined as troponin T-hypersensitivity (TNT-HSST) serum levels > 99th percentile upper reference limit (>28 pg/ml) by the American College of Cardiology/American Heart Association Task Force for myocardial infarction and non-myocardial infarction diseases, 6 was detected in approximately 7.2%-12% COVID-19 patients in previous studies. [2] [3] Furthermore, both severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) have been linked to acute myocarditis, AMI, and rapid-onset heart failure. 7-9 Reportedly, 2 nearly 40% of hospitalized patients with confirmed COVID- 19 have underlying comorbidities such as cardiovascular or cerebrovascular diseases.
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