Author: Qizhi Sun; Mohamed I. Gatie; Gregory M. Kelly
Title: Serum-dependent and independent regulation of PARP2 Document date: 2018_11_29
ID: ccfrx3md_42
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/483289 doi: bioRxiv preprint Graphical Abstract Legend Fig. 1 . Schematic representation of PARP2 regulation under different growing conditions. PARP2 maintains genomic stability by recruiting DNA repair machinery to sites of DNA damage (1), and when not required is ubiquitinated and degraded by the proteasome (2). Under stress con.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/483289 doi: bioRxiv preprint Graphical Abstract Legend Fig. 1 . Schematic representation of PARP2 regulation under different growing conditions. PARP2 maintains genomic stability by recruiting DNA repair machinery to sites of DNA damage (1), and when not required is ubiquitinated and degraded by the proteasome (2). Under stress condition (3), such as serum-starvation, PARP2 is either degraded in a proteasome-independent manner (4) or packaged into a SDS/urea-insoluble fraction (5).
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