Author: Halpin-Veszeleiova, Katarina; Hatfield, Stephen
Title: Therapeutic Targeting of Hypoxia-A2-Adenosinergic Pathway in COVID-19 Patients Cord-id: wtvel6v4 Document date: 2021_1_1
ID: wtvel6v4
Snippet: The Hypoxia-HIF-1a-A2-adenosinergic pathway protects tissues from inflammatory damage during anti-pathogen immune responses. The elimination of this physiological tissue-protecting mechanism by supplemental oxygenation may contribute to the high mortality of oxygen ventilated COVID-19 patients by exacerbating inflammatory lung damage. Engagement of this pathway using hypoxia-adenosinergic drugs may improve outcomes of these patients.
Document: The Hypoxia-HIF-1a-A2-adenosinergic pathway protects tissues from inflammatory damage during anti-pathogen immune responses. The elimination of this physiological tissue-protecting mechanism by supplemental oxygenation may contribute to the high mortality of oxygen ventilated COVID-19 patients by exacerbating inflammatory lung damage. Engagement of this pathway using hypoxia-adenosinergic drugs may improve outcomes of these patients.
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