Author: Jieyu Guo; Xiangxiang Wei; Qinhan Li; Liliang Li; Zhaohua Yang; Yu Shi; Yue Qin; Xinyue Zhang; Xinhong Wang; Xiuling Zhi; Dan Meng
Title: Single-cell RNA Analysis on ACE2 Expression Provides Insight into SARS-CoV-2 Blood Entry and Heart Injury Document date: 2020_4_4
ID: in3b1nzv_12
Snippet: To assess the cell-type specific expression of ACE2 gene in heart, we analyzed the published scRNA-seq data of adult human heart tissues from 12 healthy donors (GSE109816) and six patients with heart failure (GSE121893) 14 . After quality filtering for detected genes, we analyzed 9994 cells in normal heart tissues and 4221 cells in heart failure tissues. Four major cell types were identified, including cardiomyocytes, fibroblasts, vascular cells,.....
Document: To assess the cell-type specific expression of ACE2 gene in heart, we analyzed the published scRNA-seq data of adult human heart tissues from 12 healthy donors (GSE109816) and six patients with heart failure (GSE121893) 14 . After quality filtering for detected genes, we analyzed 9994 cells in normal heart tissues and 4221 cells in heart failure tissues. Four major cell types were identified, including cardiomyocytes, fibroblasts, vascular cells, and immune cells (Fig. S2A-S2D ). Cells in failed hearts showed a higher ACE2-positive rate than in normal hearts (7.60% of all cells vs. 5.88% of all cells). We observed higher enrichment of ACE2 expression in cardiomyocytes of All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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