Author: Day, James W.; Fox, Thomas A.; Halsey, Richard; Carpenter, Ben; Kottaridis, Panagiotis D.
Title: ILâ€1 blockade with anakinra in acute leukaemia patients with severe COVIDâ€19 pneumonia appears safe and may result in clinical improvement Cord-id: wloahziy Document date: 2020_5_21
ID: wloahziy
Snippet: As of 17th May, 2020 the number of patients infected by coronavirus disease 2019 (COVIDâ€19) worldwide has exceeded 4.5 million (WHO 2020). A subgroup of patients with COVIDâ€19 pneumonia develop a hyperinflammatory syndrome which has a similar cytokine release profile to secondary haemophagocytic lymphohistiocytosis (HLH) (Huang, et al 2020). Immunomodulatory drugs are hypothesised to abrogate the dysfunctional immune response in hyperinflammatory COVIDâ€19 and are currently being investigat
Document: As of 17th May, 2020 the number of patients infected by coronavirus disease 2019 (COVIDâ€19) worldwide has exceeded 4.5 million (WHO 2020). A subgroup of patients with COVIDâ€19 pneumonia develop a hyperinflammatory syndrome which has a similar cytokine release profile to secondary haemophagocytic lymphohistiocytosis (HLH) (Huang, et al 2020). Immunomodulatory drugs are hypothesised to abrogate the dysfunctional immune response in hyperinflammatory COVIDâ€19 and are currently being investigated in clinical trials. ILâ€1 blockage with anakinra has been shown to be safe and is associated with clinical improvement in patients with hyperinflammatory COVIDâ€19 (Cavalli, et al 2020).
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