Author: Aaron S. Mendez; Carolin Vogt; Jens Bohne; Britt A. Glaunsinger
Title: Site specific target binding controls RNA cleavage efficiency by the Kaposi’s sarcoma-associated herpesvirus endonuclease SOX Document date: 2018_5_13
ID: 298cbr1x_23
Snippet: A recent crystal structure of SOX bound to the K2-31 pre-miRNA captured the importance of the exposed loop region for SOX cleavage (21). However, the structure did not reveal additional interactions between SOX and the RNA beyond the 3 residues surrounding the cut site. Our data suggest that this is likely because the K2-31 RNA lacks the additional residues necessary for SOX binding site found in both LIMD1 and GFP......
Document: A recent crystal structure of SOX bound to the K2-31 pre-miRNA captured the importance of the exposed loop region for SOX cleavage (21). However, the structure did not reveal additional interactions between SOX and the RNA beyond the 3 residues surrounding the cut site. Our data suggest that this is likely because the K2-31 RNA lacks the additional residues necessary for SOX binding site found in both LIMD1 and GFP.
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