Author: Aleksandra Milewska; Anna Kula-Pacurar; Jakub Wadas; Agnieszka Suder; Artur Szczepanski; Agnieszka Dabrowska; Katarzyna Owczarek; Marek Ochman; Tomasz Stacel; Zenon Rajfur; Pawel Piotr Labaj; Wojciech Branicki; Krzysztof Pyrc
Title: Replication of SARS-CoV-2 in human respiratory epithelium Document date: 2020_3_21
ID: 1cc9ig04_7
Snippet: The HAE cultures reconstitute the tissue lining the conductive airways of humans. Fully 68 differentiated, are among the best tools for studying the viral infection in a natural 69 microenvironment 15 . These air-liquid interphase cultures contain a number of cell types (e.g., 70 basal, ciliated, and goblet). At the same time, they also functionally reflect the natural tissue 71 with extensive crosstalk and production of protective mucus and surf.....
Document: The HAE cultures reconstitute the tissue lining the conductive airways of humans. Fully 68 differentiated, are among the best tools for studying the viral infection in a natural 69 microenvironment 15 . These air-liquid interphase cultures contain a number of cell types (e.g., 70 basal, ciliated, and goblet). At the same time, they also functionally reflect the natural tissue 71 with extensive crosstalk and production of protective mucus and surfactant proteins 16, 17, 18 . The science, but also the antiviral drug development 12, 13, 14, 20 .
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