Selected article for: "active smoking status and low incidence"
Author: Chong, Woon H.; Saha, Biplab K.; Hu, Kurt; Chopra, Amit
Title: The Incidence, Clinical Characteristics, and Outcomes of Pneumothorax in Hospitalized COVID-19 Patients: A Systematic Review
  • Cord-id: x4pr6e4w
  • Document date: 2021_5_1
    • ID: x4pr6e4w
    Snippet: BACKGROUND: : Pneumothorax has been frequently described as complication of COVID-19 infections. OBJECTIVE: : In this systematic review, we describe the incidence, clinical characteristics, and outcomes of COVID-19-related pneumothorax. METHODS: : Studies were identified through MEDLINE, Pubmed, and Google Scholar databases using keywords of “COVID-19,” “SARS-CoV-2,” “pneumothorax,” “pneumomediastinum,” and “barotrauma” from January 1(st), 2020 to January 30(th), 2021. RESULT
    Document: BACKGROUND: : Pneumothorax has been frequently described as complication of COVID-19 infections. OBJECTIVE: : In this systematic review, we describe the incidence, clinical characteristics, and outcomes of COVID-19-related pneumothorax. METHODS: : Studies were identified through MEDLINE, Pubmed, and Google Scholar databases using keywords of “COVID-19,” “SARS-CoV-2,” “pneumothorax,” “pneumomediastinum,” and “barotrauma” from January 1(st), 2020 to January 30(th), 2021. RESULTS: : Among the nine observational studies, the incidence of pneumothorax is low at 0.3% in hospitalized COVID-19 patients. However, the incidence of pneumothorax increases to 12.8-23.8% in those requiring invasive mechanical ventilation (IMV) with a high mortality rate up to 100%. COVID-19-related pneumothorax tends to be unilateral and right-sided. Age, pre-existing lung diseases, and active smoking status are not shown to be risk factors. The time to pneumothorax diagnosis is around 9.0-19.6 days from admission and 5.4 days after IMV initiation. COVID-19-related pneumothoraces are associated with prolonged hospitalization, increased likelihood of ICU admission and death, especially among the elderly. CONCLUSION: : COVID-19-related pneumothorax likely signify greater disease severity. With the high variability of COVID-19-related pneumothorax incidence described, a well-designed study is required to better assess the significance of COVID-19-related pneumothorax.

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