Author: Pimentel-Elardo, Sheila M.; Buback, Verena; Gulder, Tobias A.M.; Bugni, Tim S.; Reppart, Jason; Bringmann, Gerhard; Ireland, Chris M.; Schirmeister, Tanja; Hentschel, Ute
Title: New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities Cord-id: wsmc0urt Document date: 2011_9_26
ID: wsmc0urt
Snippet: Four new tetromycin derivatives, tetromycins 1–4 and a previously known one, tetromycin B (5) were isolated from Streptomyces axinellae Pol001(T) cultivated from the Mediterranean sponge Axinella polypoides. Structures were assigned using extensive 1D and 2D NMR spectroscopy as well as HRESIMS analysis. The compounds were tested for antiparasitic activities against Leishmania major and Trypanosoma brucei, and for protease inhibition against several cysteine proteases such as falcipain, rhodesa
Document: Four new tetromycin derivatives, tetromycins 1–4 and a previously known one, tetromycin B (5) were isolated from Streptomyces axinellae Pol001(T) cultivated from the Mediterranean sponge Axinella polypoides. Structures were assigned using extensive 1D and 2D NMR spectroscopy as well as HRESIMS analysis. The compounds were tested for antiparasitic activities against Leishmania major and Trypanosoma brucei, and for protease inhibition against several cysteine proteases such as falcipain, rhodesain, cathepsin L, cathepsin B, and viral proteases SARS-CoV M(pro), and PL(pro). The compounds showed antiparasitic activities against T. brucei and time-dependent inhibition of cathepsin L-like proteases with K(i) values in the low micromolar range.
Search related documents:
Co phrase search for related documents- absorption band and acute respiratory syndrome: 1
- acid function and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- acid function and additional target: 1
- acid group and active site: 1
- acid group and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- active centre and acute respiratory syndrome: 1, 2, 3
- active site and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- active site and additional target: 1, 2, 3, 4
- active site and low micromolar range: 1, 2, 3, 4, 5, 6
- active site and lower molecular: 1, 2
- active site protonation state and acute respiratory syndrome: 1
- acute respiratory syndrome and additional target: 1, 2, 3, 4, 5
- acute respiratory syndrome and low micromolar range: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- acute respiratory syndrome and lower molecular: 1, 2, 3, 4, 5, 6
Co phrase search for related documents, hyperlinks ordered by date