Author: Jacob Peter Matson; Amy M. House; Gavin D. Grant; Huaitong Wu; Joanna Perez; Jeanette Gowen Cook
Title: Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence Document date: 2019_2_22
ID: dsbucda9_19
Snippet: Cells in both the first and second cell cycles also reached a similar CDK activity (cytoplasmic/nuclear ratio greater than 1) at the time of peak nuclear Cdc6 and S phase entry (Fig. 6F ) close to previously-reported values of 0.84-1.0 in other untransformed cell lines (Spencer et al., 2013; Schwarz et al., 2018) . In other words, the underlicensed first G1 cells achieved the same level of CDK activity in late G1 as normally-licensed second G1 ce.....
Document: Cells in both the first and second cell cycles also reached a similar CDK activity (cytoplasmic/nuclear ratio greater than 1) at the time of peak nuclear Cdc6 and S phase entry (Fig. 6F ) close to previously-reported values of 0.84-1.0 in other untransformed cell lines (Spencer et al., 2013; Schwarz et al., 2018) . In other words, the underlicensed first G1 cells achieved the same level of CDK activity in late G1 as normally-licensed second G1 cells. These equivalent CDK activity indicators further support the notion that the licensing checkpoint does not delay CDK2 activation in the first G1.
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