Author: Yasunori Watanabe; Joel D. Allen; Daniel Wrapp; Jason S. McLellan; Max Crispin
Title: Site-specific analysis of the SARS-CoV-2 glycan shield Document date: 2020_3_28
ID: 63j4qc7d_3
Snippet: Understanding the glycosylation of recombinant viral spikes can both reveal fundamental features of viral biology and can guide vaccine design strategies and manufacturing. As glycans are enzymatically elaborated in the Golgi apparatus, some features of processed, so-called complex-type, glycosylation will necessarily be influenced by the [11] [12] [13] [14] . However observations of hybrid-and complex-type glycans on virally derived material sug.....
Document: Understanding the glycosylation of recombinant viral spikes can both reveal fundamental features of viral biology and can guide vaccine design strategies and manufacturing. As glycans are enzymatically elaborated in the Golgi apparatus, some features of processed, so-called complex-type, glycosylation will necessarily be influenced by the [11] [12] [13] [14] . However observations of hybrid-and complex-type glycans on virally derived material suggests that the viral glycoproteins are subjected to Golgi resident processing enzymes 8, 15 .
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