Author: Timokratis Karamitros; Gethsimani Papadopoulou; Maria Bousali; Anastasios Mexias; Sotiris Tsiodras; Andreas Mentis
Title: SARS-CoV-2 exhibits intra-host genomic plasticity and low-frequency polymorphic quasispecies Document date: 2020_3_28
ID: jxm69ndw_23
Snippet: The rapid spread and the death toll of the new SARS-CoV-2 epidemic warrants the immediate identification / development of effective antiviral agents and vaccines, but also the design of accurate diagnostics. The intra-and inter-patient variability of the viral genome plays a pivotal role in all the abovementioned efforts, since it affects the compatibility of molecular diagnostics but also impairs the effectiveness of the vaccines and the serolog.....
Document: The rapid spread and the death toll of the new SARS-CoV-2 epidemic warrants the immediate identification / development of effective antiviral agents and vaccines, but also the design of accurate diagnostics. The intra-and inter-patient variability of the viral genome plays a pivotal role in all the abovementioned efforts, since it affects the compatibility of molecular diagnostics but also impairs the effectiveness of the vaccines and the serological assays by altering the antigenicity of the virus. Intra-host low-frequency variants are also the main source of resistance to anti-viral drugs.
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