Author: Tamina Park; Sang-Yeop Lee; Seil Kim; Mi Jeong Kim; Hong Gi Kim; Sangmi Jun; Seung Il Kim; Bum Tae Kim; Edmond Changkyun Park; Daeui Park
Title: Spike protein binding prediction with neutralizing antibodies of SARS-CoV-2 Document date: 2020_2_27
ID: dqxfcwyu_1
Snippet: for SARS-CoV [12] . Shi and colleges showed that SARS-CoV-2 uses ACE2 as a cellular entry receptor but not 73 other CoV receptors, aminopeptidase N (APN) and dipeptidyl peptidase 4 (DPP4) [13] . Ying and colleges 74 showed the receptor-binding domain (RBD) of SARS-CoV-2 spike glycoprotein (S protein) interacts with ACE2 75 [14] . McLaellen and colleges showed that ACE2 binds to SARS-CoV-2 S protein with much higher affinity than 76 to SARS-CoV S .....
Document: for SARS-CoV [12] . Shi and colleges showed that SARS-CoV-2 uses ACE2 as a cellular entry receptor but not 73 other CoV receptors, aminopeptidase N (APN) and dipeptidyl peptidase 4 (DPP4) [13] . Ying and colleges 74 showed the receptor-binding domain (RBD) of SARS-CoV-2 spike glycoprotein (S protein) interacts with ACE2 75 [14] . McLaellen and colleges showed that ACE2 binds to SARS-CoV-2 S protein with much higher affinity than 76 to SARS-CoV S protein [15] . In addition, bioinformatic analysis proposed binding structure of RBD of S protein 77 (S-RBD) and ACE2 [16] . Thus, it is of great interest to identify neutralizing antibodies that can interact with 78 SARS-CoV-2 S-RBD and interfere with the binding between viral S protein and host receptor ACE2.
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