Spike protein binding prediction with neutralizing antibodies of SARS-CoV-2

Tamina Park; Sang-Yeop Lee; Seil Kim; Mi Jeong Kim; Hong Gi Kim; Sangmi Jun; Seung Il Kim; Bum Tae Kim; Edmond Changkyun Park; Daeui Park

The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.22.951178 doi: bioRxiv preprint literature and PDB (Table 1) . Epitope map showed that the antibody-binding residues of S protein are located 175 within RDB region (Fig. 2) . Four SARS-CoV neutralizing antibodies had the epitopes about 5 to 14 residues SARS-CoV neutralizing antibodies might be bind to mainly conformational epitopes of S-RDB, whereas MERS-179 CoV neutralizing antibodies bound to linear epitopes of S-RBD (Fig. 2) . Interestingly, the major linear epitope 197 6NB7) which were good structural templates (Fig. 3 box) . In the S-RBD structure, we also displayed 198 experimentally defined epitope information based on position specific aligment with SARS-CoV or MERS-CoV 199 antibody binding epitopes. 200 author/funder. All rights reserved. No reuse allowed without permission.