Author: Manish Tiwari; Divya Mishra
Title: Investigating the genomic landscape in novel coronavirus (2019-nCoV) genomes to identify non-synonymous mutations for use in diagnosis and drug design Document date: 2020_4_18
ID: f0z8gcws_21
Snippet: Additionally, mutations were present in structural proteins such as, glycine to valine mutation in ORF3a (G196V and G251V). Similar amino acid change imparts resistance against inhibitor drug saquinavir in the human immunodeficiency virus type 1 (HIV-1). This might provide an explanation why drugs used for treating HIV became a failure in case of hCoV infection (Hong et al., 1997) . Notably, in ORF9 region the nucleotide sequence GGG changed to A.....
Document: Additionally, mutations were present in structural proteins such as, glycine to valine mutation in ORF3a (G196V and G251V). Similar amino acid change imparts resistance against inhibitor drug saquinavir in the human immunodeficiency virus type 1 (HIV-1). This might provide an explanation why drugs used for treating HIV became a failure in case of hCoV infection (Hong et al., 1997) . Notably, in ORF9 region the nucleotide sequence GGG changed to AAC in European and American continent resulting in a change of amino acid from RG to KR (AGGGGA coding for RG changed to AAACGA coding for KR, 28993-28995 in nucleotide alignment).
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