Selected article for: "amino acid and leucine amino"
Author: Manish Tiwari; Divya Mishra
Title: Investigating the genomic landscape in novel coronavirus (2019-nCoV) genomes to identify non-synonymous mutations for use in diagnosis and drug design
  • Document date: 2020_4_18
    • ID: f0z8gcws_26
    Snippet: Interestingly, presence of a non-synonymous substitution in RNA Dependent RNA Polymerase (RDRP) region in majority of European hCoV samples resulted in change of amino acid from proline to leucine (P314L). It will be quite interesting to validate the effect of this substitution on RDRP activity as one of the previous study established that similar change of proline-to-leucine substitution (P236L) of HIV-1 reverse transcriptase, imparts resistance.....
    Document: Interestingly, presence of a non-synonymous substitution in RNA Dependent RNA Polymerase (RDRP) region in majority of European hCoV samples resulted in change of amino acid from proline to leucine (P314L). It will be quite interesting to validate the effect of this substitution on RDRP activity as one of the previous study established that similar change of proline-to-leucine substitution (P236L) of HIV-1 reverse transcriptase, imparts resistance against a highly specific inhibitor bisheteroarylpiperazines (BHAPs) (Fan et al., 1995) . These examples clearly show that amino acid changes may significantly affect the functional competency of polymerase and the associated subunits.

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