SARS-CoV-2 infection does not significantly cause acute renal injury: an analysis of 116 hospitalized patients with COVID-19 in a single hospital, Wuhan, China

Lunwen Wang; Xun Li; Hui Chen; Shaonan Yan; Yan Li; Dong Li; Zuojiong Gong

Based on the clinical, pathologic study, and laboratory features of SARS-CoV infection in SARS patients in 2003, the data showed that acute renal impairment was uncommon, but carried a formidably high mortality (91.7%, 33 of 36 cases) [17] . In this study, all of the patients without basic kidney disease showed no obvious abnormality of renal function during the hospitalization of COVID-19, and none of the patients exhibited ARF. Be cause high homology of SARS-CoV-2 and SARS-CoV. The results of this study were similar and consistent with the presentation of renal function injury in SARS. In this study, we also observed that the patients with chronic renal failure (CRF) who were undergone regular continuous renal replacement therapy (CRRT) were infected with SARS-CoV-2, and confirmed as COVID-19. Except regular CRRT, the monitoring of renal function indicators showed stable, without exacerbation of CRF during the course of treatment of COVID-19. The re-examination of CT showed that pulmonary inflammation was gradually absorbed. Unlike a formidably high mortality in SARS complicated with renal impairment, none of the patients died from the aggravation of CRF or from COVID-19 itself caused by infection with SARS-CoV-2. It was also suggested that CRRT plays an important role in the treatment of COVID-19 complicated with CRF.