Author: Billon-Denis, Emmanuelle; Ferrier-Rembert, Audrey; Garnier, Annabelle; Cheutin, Laurence; Vigne, Clarisse; Tessier, Emilie; Denis, Jessica; Badaut, Cyril; Rougeaux, Clémence; Depeille Wuille, Anne; Timera, Hawa; Boutin, Laet itia; Drouet, Isabelle; Verguet, Noémie; Nolent, Flora; Gorgé, Olivier; Ferraris, Olivier; Tournier, Jean-Nicolas
Title: Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain Cord-id: xnjrl2ln Document date: 2021_1_2
ID: xnjrl2ln
Snippet: BACKGROUND: We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes. CASE: One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers. DISCUSSION AND CONCLUSION: Thus, host individual factors may be th
Document: BACKGROUND: We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes. CASE: One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers. DISCUSSION AND CONCLUSION: Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity.
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