Author: David Fisman; Amy Greer; Ashleigh Tuite
Title: Standardization and Age-Distribution of COVID-19: Implications for Variability in Case Fatality and Outbreak Identification Document date: 2020_4_14
ID: 63hs1loe_5
Snippet: We were struck by the absence of reported COVID-19 cases in younger 78 individuals in early reports from China. A pandemic disease is defined by the 79 novelty of the pathogen and absence of population-level immunity, such that all 80 age groups in a population should be equally susceptible to infection. Inasmuch 81 as more severe cases are more likely to be recognized, the under-recognition of 82 disease in younger individuals serves as a metric.....
Document: We were struck by the absence of reported COVID-19 cases in younger 78 individuals in early reports from China. A pandemic disease is defined by the 79 novelty of the pathogen and absence of population-level immunity, such that all 80 age groups in a population should be equally susceptible to infection. Inasmuch 81 as more severe cases are more likely to be recognized, the under-recognition of 82 disease in younger individuals serves as a metric for differential disease severity 83 by age, and also provides important information that can be used to adjust case 84 fatality ratios for likely under-reporting. Furthermore, simple approaches to 85 quantify under-reporting can inform public health prevention strategies,
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