COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters

Xu, Z.; Li, Y.; Lei, Q.; Huang, L.; Lai, D.-y.; Guo, S.-j.; Jiang, H.-w.; Hou, H.; Zheng, Y.-x.; Wang, X.-n.; Wu, J.; Ma, M.-l.; Zhang, B.; Chen, H.; Yu, C.; Xue, J.-b.; Zhang, H.-n.; Qi, H.; Yu, S.; Lin, M.; Zhang, Y.; Lin, X.; Yao, Z.; Sheng, H.; Sun, Z.; Wang, F.; Fan, X.; Tao, S.-c.

Coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2, varies with regard to symptoms and mortality rates among populations. Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19. However, differences in immune responses and clinical features among COVID-19 patients remain largely unknown. Here, we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters (COVID-ONE humoral immune). COVID-ONE humoral immunity is based on a dataset that contains the IgG/IgM responses to 21 of 28 known SARS-CoV-2 proteins and 197 spike protein peptides against 2,360 COVID-19 samples collected from 783 patients. In addition, 96 clinical parameters for the 2,360 samples and information for the 783 patients are integrated into the database. Furthermore, COVID-ONE humoral immune provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups. A set of samples of interest is easily defined by adjusting the scale bars of a variety of parameters. After the START button is clicked, one can readily obtain a comprehensive analysis report for further interpretation. COVID-ONE-humoral immune is freely available at www.COVID-ONE.cn.