Author: Cifuentes-Faura, Javier
Title: Virological Features, Diagnosis and Treatment: a Review of Covid-19 Cord-id: yaoakdni Document date: 2020_1_1
ID: yaoakdni
Snippet: Like other RNA viruses, they exhibit, in relation to DNA viruses, a wide capacity for genetic mutation and recombination that enables them to adapt to different ecological niches and to evade the host-generated immune response. [...]both SARS-CoV and MERS-CoV originate from bats. [...]evidence from phylogenetic analysis shows that COVID-19 belongs to the genus betacoronavirus, which includes SARS-CoV, which infects humans, bats and wild animals [2]. Similar to SARS-CoV, SARS-CoV-2 uses the cell
Document: Like other RNA viruses, they exhibit, in relation to DNA viruses, a wide capacity for genetic mutation and recombination that enables them to adapt to different ecological niches and to evade the host-generated immune response. [...]both SARS-CoV and MERS-CoV originate from bats. [...]evidence from phylogenetic analysis shows that COVID-19 belongs to the genus betacoronavirus, which includes SARS-CoV, which infects humans, bats and wild animals [2]. Similar to SARS-CoV, SARS-CoV-2 uses the cell receptor of angiotensin-converting enzyme 2, which is expressed in the epithelium of the airway, lung parenchyma, vascular endothelium, kidney, heart, brain, testicular tissue, and intestine. Cells such as the hepatocyte may be infected with SARS-CoV, and these do not have expression of the angiotensin 2 converting enzyme cell receptor. [...]patients with SARS-CoV-2 may also have multisystemic involvement.
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