Selected article for: "lung injury and lymphocyte count"
Author: Chen, Li-Da; Zhang, Zhen-Yu; Wei, Xiao-Jie; Cai, Yu-Qing; Yao, Weng-Zhen; Wang, Ming-Hui; Huang, Qiu-Fen; Zhang, Xiao-Bin
Title: Association between cytokine profiles and lung injury in COVID-19 pneumonia
  • Cord-id: yc9ngxsa
  • Document date: 2020_7_29
    • ID: yc9ngxsa
    Snippet: BACKGROUND: Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia. METHODS: This retrospective study was conducted in COVID-19 patients. Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. The patients were divi
    Document: BACKGROUND: Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia. METHODS: This retrospective study was conducted in COVID-19 patients. Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. The patients were divided into COVID-19 with pneumonia and without pneumonia. CT severity score and PaO(2)/FiO(2) ratio were used to assess lung injury. RESULTS: 106 patients with 12 COVID-19 without pneumonia and 94 COVID-19 with pneumonia were included. Compared with COVID-19 without pneumonia, COVID-19 with pneumonia had significantly higher serum interleukin (IL)-2R, IL-6, and tumor necrosis factor (TNF)-α. Correlation analysis showed that CT severity score and PaO(2)/FiO(2) were significantly correlated with age, presence of any coexisting disorder, lymphocyte count, procalcitonin, IL-2R, and IL-6. In multivariate analysis, log IL6 was the only independent explanatory variables for CT severity score (β = 0.397, p < 0.001) and PaO(2)/FiO(2) (β = − 0.434, p = 0.003). CONCLUSIONS: Elevation of circulating cytokines was significantly associated with presence of pneumonia in COVID-19 and the severity of lung injury in COVID-19 pneumonia. Circulating IL-6 independently predicted the severity of lung injury in COVID-19 pneumonia.

    Search related documents:
    Co phrase search for related documents
    • acute respiratory syndrome and admission second day: 1, 2, 3, 4, 5, 6
    • acute respiratory syndrome and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory syndrome and liver injury index: 1, 2
    • acute respiratory syndrome and lobe score: 1, 2, 3, 4
    • acute respiratory syndrome and low lymphocyte count: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
    • acute respiratory syndrome and lung alveolar: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory syndrome and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory syndrome and lung injury alleviate: 1, 2, 3, 4, 5
    • acute respiratory syndrome and lung injury associate: 1
    • admission patient and liver injury: 1, 2, 3, 4, 5
    • admission patient and liver injury index: 1
    • admission patient and lobe score: 1
    • admission patient and lung alveolar: 1, 2
    • admission patient and lung injury: 1, 2, 3, 4
    • admission second day and liver injury: 1
    • liver injury and low lymphocyte count: 1, 2
    • liver injury and lung alveolar: 1, 2, 3
    • liver injury and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • lobe score and lung injury: 1