Author: Ian M. Silverman; Sager J. Gosai; Nicholas Vrettos; Shawn W. Foley; Nathan D. Berkowitz; Zissimos Mourelatos; Brian D. Gregory
Title: Isolation and sequencing of AGO-bound RNAs reveals characteristics of mammalian stem-loop processing in vivo Document date: 2018_4_6
ID: 1pbshnw9_54
Snippet: We also analyzed non-templated 3' additions to pre-miRNA-seq reads mapped to AGO-associated stem-loops derived from human and mouse mRNAs (Figs. 5F-G and Table S7 ). We found that pre-miRNA-seq reads which mapped to these elements were enriched for uridylation events, and in fact, a higher percentage were oligo-tailed (13.0% in human and 24.3% in mouse), compared to reads mapping to miRBase (Figs. 2C and S2F) . This result suggests that the AGO-a.....
Document: We also analyzed non-templated 3' additions to pre-miRNA-seq reads mapped to AGO-associated stem-loops derived from human and mouse mRNAs (Figs. 5F-G and Table S7 ). We found that pre-miRNA-seq reads which mapped to these elements were enriched for uridylation events, and in fact, a higher percentage were oligo-tailed (13.0% in human and 24.3% in mouse), compared to reads mapping to miRBase (Figs. 2C and S2F) . This result suggests that the AGO-associated stem-loops derived from mRNAs identified by our approach undergo similar modifications to known pre-miRNAs.
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