SARS-CoV-2 might manipulate against its host the immunity RNAi/Dicer/Ago system Does mitochondria collapse upon COVID-19 infection?

Claude Pasquier; Alain Robichon

Considering perfect base pairing over a length of at least 20 bases, we computationally identified the transcripts of 7 known coding human genes that are theoretically complementary to a segment 4 . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.08.031856 doi: bioRxiv preprint originating from SARS-CoV-2 RNA. Results are summarized in Table 1 Among the human genes, we noticed the presence of DNAJC13 (which regulates endosomal membrane trafficking [18] ), FBXO21 (a F-box protein that is one of the four subunits of ubiquitin protein ligase complex [19] ), FLRT2 (which encodes a fibronectin leucine rich transmembrane (FLRT) acting as cell adhesion molecule), ELP4 (which encodes an histone acetyltransferase, a subunit associated with RNA polymerase type II), USP31 (an ubiquitine specific peptidase that has been described to activate transcription factor NF-kappaB that stimulates interferon synthesis [16] ) and USP30 (a mitochondrial ubiquitin specific peptidase [15] ). The segment of pairing in USP30 was found exclusively in humans, which highlights its unexpected and intriguing presence in The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.08.031856 doi: bioRxiv preprint