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Author: Rosenthal, Sun Hee; Kagan, Ron M.; Gerasimova, Anna; Anderson, Ben; Grover, David; Hua, Michael; Liu, Yan; Owen, Renius; Lacbawan, Felicitas
Title: Identification of eight SARS-CoV-2 ORF7a deletion variants in 2,726 clinical specimens
  • Cord-id: zdx77tfv
  • Document date: 2020_12_11
  • ID: zdx77tfv
    Snippet: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF7a, the ortholog of SARS-CoV ORF7a, is a type I transmembrane protein and plays an important role in virus-host interactions. Deletion variants in ORF7a may influence virulence, but only a few such isolates have been reported. Here, we report 8 unique ORF7a deletion variants of 6 to 96 nucleotides in length identified from 2,726 clinical specimens collected in March of 2020.
    Document: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF7a, the ortholog of SARS-CoV ORF7a, is a type I transmembrane protein and plays an important role in virus-host interactions. Deletion variants in ORF7a may influence virulence, but only a few such isolates have been reported. Here, we report 8 unique ORF7a deletion variants of 6 to 96 nucleotides in length identified from 2,726 clinical specimens collected in March of 2020.

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