Author: Nimir, Mohammed; Tank, Atisha; Snead, David
Title: COVID-19 post-mortem findings: how the departed can teach us Cord-id: xz31y8vb Document date: 2021_7_29
ID: xz31y8vb
Snippet: We present an asthmatic 39 year old female frontline healthcare worker in contact with COVID-19 patients, who suffered from respiratory problems for a few days, after which she was found dead by her spouse. Post-mortem (PM) examination showed lung consolidation and histological evidence of diffuse alveolar damage (DAD), in form of hyaline membrane disease, as well as atypical cells, thrombi and fibrin plugs inside pulmonary capillaries. Swab sample testing for SARS-CoV-2 confirmed the infection
Document: We present an asthmatic 39 year old female frontline healthcare worker in contact with COVID-19 patients, who suffered from respiratory problems for a few days, after which she was found dead by her spouse. Post-mortem (PM) examination showed lung consolidation and histological evidence of diffuse alveolar damage (DAD), in form of hyaline membrane disease, as well as atypical cells, thrombi and fibrin plugs inside pulmonary capillaries. Swab sample testing for SARS-CoV-2 confirmed the infection status. SARS-CoV-2 is a novel coronavirus which first emerged in Wuhan, China, and PM is contributing immensely to uncovering the pathophysiological mechanism of this disease. SARS-CoV-2 enters host cells via the angiotensin-converting enzyme 2 (ACE2), and can lead to a fatal pneumonia characterised histologically by DAD (the most consistent PM finding). This is due to invasion by the virus of type II pneumocytes, which leads to the death of both type I and II pneumocytes and increased capillary permeability. This compromises gas exchange which can lead eventually to cardiorespiratory failure and death.
Search related documents:
Co phrase search for related documents- acute ards respiratory distress syndrome and lung parenchyma: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- acute ards respiratory distress syndrome and lung specimen: 1
- acute ards respiratory distress syndrome and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute ards respiratory distress syndrome and lymph node: 1, 2
- acute ards respiratory distress syndrome and lymphoid cell: 1
- acute fibrinous organising pneumonia and lung tissue: 1
- acute phase and lung parenchyma: 1, 2, 3, 4
- acute phase and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- acute phase and lymph node: 1, 2, 3, 4, 5
- acute phase and lymphoid cell: 1
- acute phase virus and lung parenchyma: 1
- acute phase virus and lung tissue: 1, 2, 3
- lung finding and lymph node: 1
- lung parenchyma and lymph node: 1, 2, 3, 4, 5, 6, 7
- lung tissue and lymph node: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- lung tissue and lymphoid cell: 1, 2
Co phrase search for related documents, hyperlinks ordered by date