Author: Pérez-Galarza, Jorge; Prócel, César; Cañadas, Cristina; Aguirre, Diana; Pibaque, Ronny; Bedón, Ricardo; Sempértegui, Fernando; Drexhage, Hemmo; Baldeón, Lucy
Title: Immune Response to SARS-CoV-2 Infection in Obesity and T2D: Literature Review Cord-id: u65x0dy7 Document date: 2021_1_29
ID: u65x0dy7
Snippet: In December 2019, a novel coronavirus known as SARS-CoV-2 was first detected in Wuhan, China, causing outbreaks of the coronavirus disease COVID-19 that has now spread globally. For this reason, The World Health Organization (WHO) declared COVID-19 a public health emergency in March 2020. People living with pre-existing conditions such as obesity, cardiovascular diseases, type 2 diabetes (T2D), and chronic kidney and lung diseases, are prone to develop severe forms of disease with fatal outcomes
Document: In December 2019, a novel coronavirus known as SARS-CoV-2 was first detected in Wuhan, China, causing outbreaks of the coronavirus disease COVID-19 that has now spread globally. For this reason, The World Health Organization (WHO) declared COVID-19 a public health emergency in March 2020. People living with pre-existing conditions such as obesity, cardiovascular diseases, type 2 diabetes (T2D), and chronic kidney and lung diseases, are prone to develop severe forms of disease with fatal outcomes. Metabolic diseases such as obesity and T2D alter the balance of innate and adaptive responses. Both diseases share common features characterized by augmented adiposity associated with a chronic systemic low-grade inflammation, senescence, immunoglobulin glycation, and abnormalities in the number and function of adaptive immune cells. In obese and T2D patients infected by SARS-CoV-2, where immune cells are already hampered, this response appears to be stronger. In this review, we describe the abnormalities of the immune system, and summarize clinical findings of COVID-19 patients with pre-existing conditions such as obesity and T2D as this group is at greater risk of suffering severe and fatal clinical outcomes.
Search related documents:
Co phrase search for related documents- acute ards respiratory distress syndrome and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute ards respiratory distress syndrome and adaptive immune system: 1, 2, 3, 4
- acute ards respiratory distress syndrome and adaptive immunity: 1, 2, 3, 4, 5, 6, 7
- acute ards respiratory distress syndrome and adaptive immunity innate: 1, 2, 3, 4, 5
- acute ards respiratory distress syndrome and adaptive innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- acute ards respiratory distress syndrome and adaptive innate response: 1, 2, 3, 4, 5, 6, 7
- acute ards respiratory distress syndrome and adequate gas exchange: 1, 2, 3, 4
- acute ards respiratory distress syndrome and adhesion molecule: 1, 2, 3, 4, 5, 6
- acute ards respiratory distress syndrome and adipose tissue: 1, 2, 3, 4
- acute ards respiratory distress syndrome and low affinity: 1
- acute ards respiratory distress syndrome and low amount: 1
- acute ards respiratory distress syndrome and low grade chronic: 1, 2
- acute ards respiratory distress syndrome and low incidence: 1, 2, 3, 4, 5, 6
- acute ards respiratory distress syndrome and low number: 1
- acute ards respiratory distress syndrome and lung epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute ards respiratory distress syndrome and lung parenchyma: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- acute ards respiratory distress syndrome and lymph node: 1, 2
- acute ards respiratory distress syndrome and lymphocyte count: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37
- acute ards respiratory distress syndrome and macrophage activation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
Co phrase search for related documents, hyperlinks ordered by date