Selected article for: "chromatin accessibility and viral entry"
Author: Allen Wang; Joshua A Chiou; Olivier B Poirion; Justin Buchanan; Michael J Valdez; Jamie M Verheyden; Xiaomeng Hou; Minzhe Guo; Jacklyn M Newsome; Parul Kudtarkar; Dina A Faddah; Kai Zhang; Randee E Young; Justinn Barr; Ravi Misra; Heidie Huyck; Lisa Rogers; Cory Poole; Jeffery A Whitsett; Gloria Pryhuber; Yan Xu; Kyle J Gaulton; Sebastian Preissl; Xin Sun
Title: Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection
  • Document date: 2020_4_14
    • ID: 5kvq6jtx_38
    Snippet: The observed increase in the proportion of cells expressing viral entry genes is further 470 corroborated by age-related changes in accessible chromatin, which offers insight for 471 using gene regulatory mechanisms to restrict the expression of viral entry genes. For 472 example, at the TMPRSS2 locus we identified 10 accessible chromatin sites that showed 473 significantly increased accessibility with age. These sites may therefore represent cis.....
    Document: The observed increase in the proportion of cells expressing viral entry genes is further 470 corroborated by age-related changes in accessible chromatin, which offers insight for 471 using gene regulatory mechanisms to restrict the expression of viral entry genes. For 472 example, at the TMPRSS2 locus we identified 10 accessible chromatin sites that showed 473 significantly increased accessibility with age. These sites may therefore represent cis 474 regulatory elements that contribute to activation of TMPRSS2 gene expression in an 475 increasing number of cells in adults and represent possible sites to modulate in order to 476 restrict expression. Furthermore, one of the age-dependent sites harbors a sequence 477 . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.12.037580 doi: bioRxiv preprint variant (rs35074065) significantly associated with TMPRSS2 expression and respiratory 478 phenotypes, suggesting it may be of particular value in this context. 479

    Search related documents:
    Co phrase search for related documents
    • accessible chromatin and entry gene: 1, 2, 3
    • accessible chromatin and gene expression: 1, 2, 3, 4, 5, 6, 7, 8
    • accessible chromatin and regulatory element: 1, 2
    • adult cell and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • adult cell and increase number: 1, 2
    • adult cell and observed increase: 1
    • chromatin site and gene expression: 1
    • entry gene and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • entry gene and observed increase: 1
    • entry gene and restrict expression: 1
    • gene expression and increase number: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • gene expression and observed increase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
    • gene expression and possible site: 1, 2
    • gene expression and regulatory element: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • gene expression and regulatory mechanism: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
    • gene expression and restrict expression: 1, 2, 3, 4, 5, 6
    • gene expression and significantly increase: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • gene regulatory mechanism and regulatory mechanism: 1, 2, 3, 4
    • increase number and observed increase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25