Author: DE Lorenzo, Rebecca; Cinel, Elena; Cilla, Marta; Compagnone, Nicola; Ferrante, Marica; Falbo, Elisabetta; Patrizi, Alessandro; Castellani, Jacopo; Magnaghi, Cristiano; Calvisi, Stefania L; Arcidiacono, Teresa; Lanzani, Chiara L; Canti, Valentina; Mazza, Mario G; Martinenghi, Sabina; Vitali, Giordano; Benedetti, Francesco; Ciceri, Fabio; Conte, Caterina; Rovere Querini, Patrizia
Title: Physical and psychological sequelae at three months after acute illness in COVID-19 survivors. Cord-id: ziq1f940 Document date: 2021_6_1
ID: ziq1f940
Snippet: BACKGROUND Coronavirus disease 2019 (COVID-19) may leave behind an altered health status early after recovery. We evaluated the clinical status of COVID-19 survivors at three months after hospital discharge. METHODS In this prospective observational cohort study, hospitalized patients aged ≥18 years, evaluated at one (M1) and three (M3) months post-discharge were enrolled. 251 patients (71.3% males, median [IQR] age 61.8 [53.5-70.7] years) were included. Median (IQR) time from discharge to M3
Document: BACKGROUND Coronavirus disease 2019 (COVID-19) may leave behind an altered health status early after recovery. We evaluated the clinical status of COVID-19 survivors at three months after hospital discharge. METHODS In this prospective observational cohort study, hospitalized patients aged ≥18 years, evaluated at one (M1) and three (M3) months post-discharge were enrolled. 251 patients (71.3% males, median [IQR] age 61.8 [53.5-70.7] years) were included. Median (IQR) time from discharge to M3 was 89 (79.5-101) days. Primary outcome was residual respiratory dysfunction (RRD), defined by tachypnea, moderate to very severe dyspnea, or peripheral oxygen saturation ≤95% on room air at M3. RESULTS RRD was found in 30.4% of patients, with no significant difference compared with M1. Chronic obstructive pulmonary disease and length of stay were independent predictors of RRD at multivariable logistic regression (odds ratio, OR, [95% confidence interval, CI] 4.13 [1.17-16.88], p 0.033; OR [95% CI] 1.02 [1.00-1.04], p 0.047, respectively). Obesity and C-reactive protein levels upon admission were additional predictors at regression tree analysis. Impaired quality of life (QoL) was reported by 53.2% of patients. Anxiety and insomnia were each present in 25.5% of patients, and PTSD in 22.4%. No difference was found between M1 and M3 in QoL, anxiety or PTSD. Insomnia decreased at M3. Current major psychiatric disorder as well as anxiety, insomnia and PSTD at M1 independently predicted PTSD at M3. CONCLUSIONS Clinical damage may persist at three months after discharge in COVID-19 survivors. Post-recovery follow-up is an essential component of patient management.
Search related documents:
Co phrase search for related documents- admission protein level and logistic regression: 1, 2
- logistic regression and m1 compare: 1
Co phrase search for related documents, hyperlinks ordered by date