Selected article for: "functional structure and secondary structure"
Author: Ramya Rangan; Ivan N. Zheludev; Rhiju Das
Title: RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses
  • Document date: 2020_3_28
    • ID: kjeqdse5_18
    Snippet: Currently known RNA structures that recur across betacoronaviruses provide potential starting points for therapeutic development targeting the SARS-CoV-2 RNA genome. Here, we include secondary structures for the 5´ UTR (Figure 4a ), frame-shifting element (Figure 4b ), and 3´ UTR ( Figure 4c ) for SARS-CoV-2, built by analyzing homology to literature-annotated structures in related betacoronaviruses. We additionally include computer-readable se.....
    Document: Currently known RNA structures that recur across betacoronaviruses provide potential starting points for therapeutic development targeting the SARS-CoV-2 RNA genome. Here, we include secondary structures for the 5´ UTR (Figure 4a ), frame-shifting element (Figure 4b ), and 3´ UTR ( Figure 4c ) for SARS-CoV-2, built by analyzing homology to literature-annotated structures in related betacoronaviruses. We additionally include computer-readable secondary structures in Table 4 and Supplementary File 1. A brief review of salient secondary structure features in these regions and their putative functional roles in the betacoronavirus life cycle follows.

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