Author: Ramya Rangan; Ivan N. Zheludev; Rhiju Das
Title: RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses Document date: 2020_3_28
ID: kjeqdse5_24
Snippet: Beyond the secondary structures highlighted here, prior work has pinpointed a variety of RNA-RNA interactions important to the betacoronavirus life cycle. Long-range interactions between the 5´ UTR and 3´ UTR have been implicated in RNA synthesis, for instance with mutations in the 5´ UTR SL1 only supporting viral replication when co-evolving with specific mutations in the 3´ UTR. 13, 30 Such long-range RNA-RNA interactions would be missed in.....
Document: Beyond the secondary structures highlighted here, prior work has pinpointed a variety of RNA-RNA interactions important to the betacoronavirus life cycle. Long-range interactions between the 5´ UTR and 3´ UTR have been implicated in RNA synthesis, for instance with mutations in the 5´ UTR SL1 only supporting viral replication when co-evolving with specific mutations in the 3´ UTR. 13, 30 Such long-range RNA-RNA interactions would be missed in our analyses above which have focused on shorter windows. In related coronaviruses, RNA structures that act as packaging signals have been identified in genomic ORFs. 13 Such packaging signals may reside in regions identified here from our RNAz computational analysis or may have been missed.
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