Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_55
Snippet: An additional finding of interest is that phospho-Ub-dependent parkin degradation does not appear to require parkin's mitochondrial poly-ubiquitination activity, since Mfn2 polyubiquitination and loss did not occur in response to L-DOPA, despite robust parkin loss, and since parkin overexpression did not increase phospho-poly-Ub formation. This was unexpected . CC-BY-NC-ND 4.0 International license is made available under a The copyright holder f.....
Document: An additional finding of interest is that phospho-Ub-dependent parkin degradation does not appear to require parkin's mitochondrial poly-ubiquitination activity, since Mfn2 polyubiquitination and loss did not occur in response to L-DOPA, despite robust parkin loss, and since parkin overexpression did not increase phospho-poly-Ub formation. This was unexpected . CC-BY-NC-ND 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/484857 doi: bioRxiv preprint because PINK1 and parkin participate in a well-established positive feedback loop that relies on the activity of both enzymes to generate phospho-poly-Ub during mitophagy initiation [50] .
Search related documents:
Co phrase search for related documents- additional finding and International license: 1, 2
- cc NC ND International license and enzyme activity: 1, 2
- cc NC ND International license and feedback loop: 1, 2, 3
- cc NC ND International license and International license: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cc NC ND International license and mitophagy initiation: 1
- cc NC ND International license and parkin degradation: 1, 2
- cc NC ND International license and parkin loss: 1, 2, 3, 4, 5, 6, 7
- cc NC ND International license and phospho poly ub: 1, 2, 3
- cc NC ND International license and phospho ub dependent parkin degradation: 1
- cc NC ND International license and poly ubiquitination: 1, 2
- enzyme activity and International license: 1, 2
- enzyme activity and parkin loss: 1
- feedback loop and International license: 1, 2, 3, 4
- feedback loop and mitophagy initiation: 1
- feedback loop and parkin loss: 1
- feedback loop and phospho poly ub: 1
- feedback loop and poly ubiquitination: 1
- International license and mitophagy initiation: 1
- International license and parkin degradation: 1, 2
Co phrase search for related documents, hyperlinks ordered by date