Author: Yonghua Wu
Title: Strong evolutionary convergence of receptor-binding protein spike between COVID-19 and SARS-related coronaviruses Document date: 2020_3_4
ID: 4ihv80au_2
Snippet: Considering that 2019-nCoV and SARS-CoV are distantly related, but show high similarity in the RBD protein structure and can use the same cell receptor, ACE2 5-11 , an evolutionary convergence may have occurred between them. In the present study, we employ a recently developed molecular phyloecological approach 14-16 , which uses a comparative phylogenetic analysis of functional gene sequences to determine the genetic basis of phenotypic evolutio.....
Document: Considering that 2019-nCoV and SARS-CoV are distantly related, but show high similarity in the RBD protein structure and can use the same cell receptor, ACE2 5-11 , an evolutionary convergence may have occurred between them. In the present study, we employ a recently developed molecular phyloecological approach 14-16 , which uses a comparative phylogenetic analysis of functional gene sequences to determine the genetic basis of phenotypic evolution, and we examine the possible molecular basis underlying the phenotypic convergence between 2019-nCoV and SARS-CoV. Our results reveal positive selection signals and evolutionary convergent amino acid sites of the spike protein in both 2019-nCoV and SARS-CoV and their related coronaviruses, providing new insights into understanding the evolutionary origin of their phenotypic convergence.
Search related documents:
Co phrase search for related documents- cell receptor and evolutionary origin: 1, 2, 3, 4
- cell receptor and gene sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9
- cell receptor and genetic basis: 1, 2, 3
- cell receptor and high similarity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- cell receptor and molecular basis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- cell receptor and new insight: 1, 2, 3, 4, 5, 6
- cell receptor and new insight provide: 1, 2
- cell receptor and phenotypic convergence: 1
- convergent amino acid and evolutionary convergence: 1, 2, 3
- convergent amino acid and high similarity: 1, 2, 3, 4
- convergent amino acid and molecular basis: 1
- convergent amino acid and phenotypic convergence: 1
- convergent amino and evolutionary convergence: 1, 2, 3
- convergent amino and high similarity: 1, 2, 3, 4
- convergent amino and molecular basis: 1
- convergent amino and phenotypic convergence: 1
- evolutionary convergence and high similarity: 1, 2
- evolutionary convergence and molecular basis: 1
- evolutionary convergence and phenotypic convergence: 1
Co phrase search for related documents, hyperlinks ordered by date