Selected article for: "kinase activity and PKR kinase activity"
Author: Kapil, Parul; Stohlman, Stephen A.; Hinton, David R.; Bergmann, Cornelia C.
Title: PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis
  • Cord-id: umn83919
  • Document date: 2014_5_1
    • ID: umn83919
    Snippet: Double-stranded RNA-dependent protein kinase (PKR) regulates antiviral activity, immune responses, apoptosis and neurotoxicity. Gliatropic coronavirus infection induced PKR activation in infected as well uninfected cells within the central nervous system (CNS). However, PKR deficiency only modestly increased viral replication and did not affect IFN-α/β or IL-1β expression. Despite reduced Il-6, Ccl5, and Cxcl10 mRNA, protein levels remained unaltered. Furthermore, PKR deficiency selectively r
    Document: Double-stranded RNA-dependent protein kinase (PKR) regulates antiviral activity, immune responses, apoptosis and neurotoxicity. Gliatropic coronavirus infection induced PKR activation in infected as well uninfected cells within the central nervous system (CNS). However, PKR deficiency only modestly increased viral replication and did not affect IFN-α/β or IL-1β expression. Despite reduced Il-6, Ccl5, and Cxcl10 mRNA, protein levels remained unaltered. Furthermore, PKR deficiency selectively reduced IL-10 production in CD4, but not CD8 T cells, without affecting CNS pathology. The results demonstrate the ability of PKR to balance neuroinflammation by selectively modulating key cytokines and chemokines in CNS resident and CD4 T cells.

    Search related documents:
    Co phrase search for related documents
    • activated pkr and acute infection: 1
    • activation signal and acute infection: 1, 2, 3
    • activation signal and adaptive immunity: 1, 2, 3
    • activation signal and adaptive innate: 1, 2, 3, 4, 5
    • activation signal and adaptive innate response: 1, 2, 3
    • acute infection and adaptive immune control: 1
    • acute infection and adaptive immunity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute infection and adaptive innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute infection and adaptive innate response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • acute infection and adherent cell: 1, 2
    • acute jhmv encephalomyelitis and adaptive immune control: 1
    • acute jhmv encephalomyelitis and adaptive innate: 1, 2
    • acute viral encephalitis and adaptive innate: 1