Author: Jieyu Guo; Xiangxiang Wei; Qinhan Li; Liliang Li; Zhaohua Yang; Yu Shi; Yue Qin; Xinyue Zhang; Xinhong Wang; Xiuling Zhi; Dan Meng
Title: Single-cell RNA Analysis on ACE2 Expression Provides Insight into SARS-CoV-2 Blood Entry and Heart Injury Document date: 2020_4_4
ID: in3b1nzv_14
Snippet: Given that ACE2 gene is highly expressed in arterial vascular cells, we next employed gene ontology (GO) enrichment analysis among ACE2-expressing arterial vascular cells (cluster 7, GJA4and HES1-positive cells) in the normal hearts. The highly expressed genes in these vascular cells were associated with virus infection response, including viral process, response to the virus, and response to interferongamma (Fig. S3A) . Kyoto encyclopedia of gen.....
Document: Given that ACE2 gene is highly expressed in arterial vascular cells, we next employed gene ontology (GO) enrichment analysis among ACE2-expressing arterial vascular cells (cluster 7, GJA4and HES1-positive cells) in the normal hearts. The highly expressed genes in these vascular cells were associated with virus infection response, including viral process, response to the virus, and response to interferongamma (Fig. S3A) . Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis revealed that these highly expressed genes might be involved in viral myocarditis and pathogenic Escherichia coli infection, indicating that these arterial vascular cells may be the afferent pathway of infectious heart diseases (Fig. S3B) .
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